Mission: The Center for Magnesium Education & Research is dedicated to the Health of Humankind by promoting knowledge of nutritional magnesium and its peer-reviewed science.
We are Independent Scholars
Andrea Rosanoff, Ph.D. is Director of Research & Science Information Outreach for the Center.
In 1982, Andrea Rosanoff received her Ph.D. degree in Nutrition from the University of California at Berkeley.
In 1985, Dr. Andrea Rosanoff was invited to give a short commentary upon an environmental technology proposal that included magnesium. To prepare, she went to the library to learn what she could about magnesium and was surprised to find research that linked nutritional magnesium both clinically and in population studies to heart disease -- the largest killer in her country, the United States. These were links she had not learned about during her graduate education which specialized in the nutritional minerals. Her interest piqued, Dr. Rosanoff kept reading about magnesium every chance she got at her jobs as Senior Chemical Information Specialist at Dialog Information Services and as Information Analyst at Chevron Research & Technology Corporation. At both jobs she became adept at online searching of the peer reviewed scientific literature, a skill which serves her well today as an Independent Scholar with expertise in Nutritional Magnesium.
By the late 1990’s, Dr. Rosanoff ‘s “hobby” evolved into co-authorship with Dr. Mildred Seelig in the writing of “The Magnesium Factor”, a book on magnesium and heart disease, and from there to original research and publication in scientific journals. In 2005, Dr. Rosanoff formed the Center for Magnesium Education & Research, LLC. The center conducts research into all aspects of nutritional magnesium and attempts to inform the world of their findings.
Michael Plesset is a Senior Research Fellow at the Center. He is our mathematician.
Michael Plesset did undergraduate and graduate work in mathematics. He worked in technical and management positions at the Cal Tech Jet Propulsion Laboratory for 19 years, where he was Director of Computing and Information Systems. He later worked at The Aerospace Corporation, and three early stage companies in the computer industry. Mike has spent of his "free" time writing material for a stand up comedian, attending seminary, publishing a number of short stories, and teaching English to Chinese people, among other things. He lives in SanGabriel, California with his wife Shu Mei.
Rebecca Bortz Costello, Ph.D., researched and wrote her Ph.D. dissertation on Magnesium nutrition in heart diseased and healthy humans. She has retained her avid interest in Magnesium ever since. Dr. Costello retired from the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) in September 2011 and continues to work with ODS as a part-time scientific consultant. Dr. Costello held the position of Director of Grants and Extramural Activities for the ODS for five years, beginning in May 2006. Prior to this, she served as Deputy Director from January 1999 to April 2006 and Acting Director from January 1999 to October 1999. She also organized workshops and conferences on topics of national interest in dietary supplements, conducting scientific reviews to identify gaps in scientific knowledge, and initiating and coordinating research efforts among NIH Institutes and other federal agencies.
Dr. Costello recently participated on an IND development writing team for a novel nutrient ingredient and as expert reviewer for a health claim review. She also serves as a peer-reviewer for a number of nutrition related journals.
Prior to her NIH appointment, Dr. Costello was with the Food and Nutrition Board of the National Academy of Sciences, serving as Project Director for the Committee on Military Nutrition Research. Her work focused on evaluating the nutritional adequacy and use of nutritional supplements for sustaining and enhancing performance in military personnel.
From 1987 to 1996, Dr. Costello served as a Research Associate and Program Director for the Risk Factor Reduction Center, a referral center at the Washington Adventist Hospital for the detection, modification, and prevention of cardiovascular disease through dietary and/or drug interventions. Prior to this, she held a position as Research Biologist at the Veterans Administration Medical Center in Washington, D.C.
Dr. Costello received a B.S. and M.S. in biology from the American University, Washington, D.C., and a Ph.D. in clinical nutrition from the University of Maryland at College Park in 1994. Her clinical research focused on the assessment of magnesium status in patients with congestive heart failure.
Dr. Costello maintains active membership in the American Society for Nutrition, American Heart Association, and the Southern Society for Clinical Investigation. She is also an adjunct assistant professor in the Department of Military and Emergency Medicine of the Uniformed Services University of the Health Sciences in Bethesda, Md. She is the author of articles in professional journals and textbooks, and has been an invited speaker at numerous professional meetings.
Dr. Costello’s areas of research interest include methods of systematic review, mineral nutrition and dietary interventions to reduce cardiovascular disease.
In Memory of Dr. Mildred Seelig, 1920 - 2005
Dr. Mildred Seelig provided the world with several important research papers on magnesium as she encouraged many in the struggling fields of magnesium research and therapy. We provide here her last C.V. as a tribute to her contribution to the world's knowledge of nutritional magnesium and its impact on human health.
Mildred S. Seelig, M.D., MPH
August 20, 1920 - January 14, 2005
MARITAL STATUS: Widow - 2 children; 6 grandchildren
NATIONAL BOARD EXAMINATIONS (Parts I, II, III): Completed 1948
EDUCATION: A.B. Hunter College, New York, NY, 1942
M.D. New York Medical College, 1945
M.P.H. Columbia Univ School of Public Health, 1950
TRAINING: Interne (Rotating) Orange County Hospital, CA, 1945-1946
Health Officer-in Training, NYC Dept of Health, 1948-1950
New York Medical College, Pharmacology Department Adjunct Assistant Professor, 1964-1971; Adjunct Associate Professor, 1971-1977
Goldwater Memorial Hospital, New York University Medical Center Attending Physician, Nutrition and Metabolism, 1973-1983 Associate Professor, Clinical Medicine, 1979-1984
New York Medical College, Preventive/Community Medicine Adjunct Professor, 1985-1992
Univ of North Carolina, Chapel Hill, School of Public Health Adjunct Professor, Nutrition Department, 1992 to date
HONORS: Silver Medal, French National Academy of Medicine
Honorary Scientific Consultant, Polish Academy of Science
Vice Chairman of 1st Gordon Research Conference on Magnesium
Chairman of 2nd Gordon Research Conference on Magnesium
First Master of the American College of Nutrition
Festschrift in Honor of MS Seelig: J Am Coll Nutr (Oct, 1994)
Mildred Seelig Award Lectureship of Great Lakes Medical Association 2000
Seelig Magnesium Award Lectureship of the American College of Nutrition 2000 -
POSITIONS IN THE AMERICAN COLLEGE OF NUTRITION:
Member of Board of Directors, 1974-1978
Vice President, 1978-1980,
President, 1980-1982, Executive Director, 1982-1994
EDITORSHIP of Journals:
Editor-in Chief of J of American College of Nutrition for 12 years (1982-1994)
Associate Editor, Magnesium Bulletin
" " J of Nutritional Medicine
BOOKS by MS Seelig:
1977. Editor: Nutritional Imbalances in Infant and Adult Diseases.
1979. Co-Editor: Nutrition and Cancer (with J Van Eys & B Nichols)
1980. Author: Magnesium in the Pathogenesis of Disease: Early Roots of
Cardiovascular, Skeletal and Renal Abnormalities. Publ: Plenum Press, NY
1980: Co-Editor: Magnesium in Health and Disease (with M Cantin)
1987: Co-Editor: Magnesium in Cellular Processes and Medicine
(with BM Altura, & J Durlach).
2003: Co-Author: The Magnesium Factor; Prevention, Treatment and Reversal of Cardiovascular Disease, Publ. Avery, Penguin Putnam (with Andrea Rosanoff)
Note: Interviews by radio commentators concerning magnesium in health and disease, and concerning the book.
REFEREE OF SUBMITTED MANUSCRIPTS TO:
J American College of Nutrition
J Nutritional Biochemistry
J Clinical Endocrinology & Metabolism
American J Clinical Nutrition
Archives of Internal Medicine
American J Hypertension
Nutrition: International J of Appl & Basic Nutr Sci
J of Nutritional & Environmental Medicine
Southern Medical Journal
REFEREE OF RESEARCH APPLICATIONS on CLINICAL RESEARCH on MAGNESIUM
National Institute of Health, U.S.A.
National Science Foundation, U.S.A.
Department of Health & Welfare, Canada
Ministry of Health, Switzerland
Invited Panelist in Workshop on Magnesium Intervention Studies to Decrease Incidence of Sudden Cardiac Death (Bureau of Epidemiology, Dept Health & Welfare, Ottawa, Canada) -- 1993-1994
Consultant for protocol, investigator selections for NIH-supported multi-institution study of Mg-infusions for acute myocardial infarction
Consultant for MAGIC study (by E Antman, Chief of Planning Committee, NIH) 1997-1998
PROGRAM PLANNER FOR SCIENTIFIC MEETINGS
1975: Planner and Chairman: Annual Meeting of American College of Nutrition:
Minerals, Vitamin D, and Cholesterol in Infant and Adult Diseases
1976: U.S.A. Coordinator of Program Planning Committee, & Vice President,
2nd International Symposium on Magnesium, Montreal, Canada
1977: Co-Chairman & Co-Planner, ACN Annual Meeting: Nutrition and Cancer
1978: Chairman & Planner, ACN Annual Meeting: Early Roots of Cardiovascular Disease.
1978: Vice Chairman of1st Gordon Research Conf on Magnesium, Plymouth, NH
1979: Chairman of2nd Gordon Research Conf on Magnesium, Plymouth, NH
1979: Co-Chairman & Co-Planner, ACN Annual Meeting: Magnesium & Trace Substances in Hypertension and Renal Disease.
1981: U.S.A. Coordinator of Program Planning & Vice President,
3rd International Symposium on Magnesium, Baden Baden, Germany
1985: President and Program Planner, 4th Int'l Sympos on Magnesium, Blacksburg, VA
1993: Member of Program Planning Panel, Hospital Assoc of Canada; Toronto, Canada
Int'l Sympos on Nutritional Intervention in Medical Care,
INVITED INTERNATIONAL LECTURE TOURS:
1978: Scotland and England
- Univ of Edinburgh, Scotland: At invitation of John O Forfar, Chairman of Health & Life Dept, Moderated Program; lectured on Perinatal & Pediatric Origins of Cardiovascular Disease
- Freeman Hospital, Newcastle-on-Tyne, England, at invitation of M Holden,Consultant Cardiothoracic Surgeon; lecture:Magnesium deficiency and therapy in cardiac disease.
- Univ of Leeds, at invitation of Nicholas J Birch, Prof of Biochemistry, lecture:Gestational and neonatal magnesium deficiency.
- Univ of Manchester,Pediatrics Dept, at invitation of Chairman,John O. Davis: lecture: Magnesium deficiency and excesses of vitamin D and phosphate in infancy.
- Univ of Surrey, Guildford, England, Symposium on Treatment of Fungal Infections, Co-Chaired Session on Fungal Endocarditis; lecture: Patients at risk of fungal endocarditis; diagnosis, treatment.
- University of Helsinki, Invited Lectures:
Dietary imbalances in high incidence of cardiovascular disease in Finland, nutritional roots.
- to Department of Cardiology: Magnesium and the myocardium.
- Univ of Kuopio, Invited Lecture: Magnesium deficiency - effects on arteries and myocardium; retention of sodium, potassium and calcium.
- Univ of Kuopio, Staff of North Karelia Project, Research seminar,Lecture and Discussion: Nutritional imbalances (low Mg, high Ca, vitamin D, phosphate, fat, and salt) prenatally and in infancy and childhood; possible cardiovascular and renal damage.
- Univ of Helsinki, Central Hospital, Lecture: Deficiencies of magnesium & trace substances; carcinogenesis and impaired immumosurveillance.
PRESENTATIONS AT SYMPOSIA
INVITED PLENARY SESSION LECTURER; CHAIRMAN OF SESSIONS AT SYMPOSIA
1966: Annual Meeting of Medical Mycology Society of New York. Invited Lecture:
Research approaches to the problem of antibiotics' effects on host defenses against Candida albicans.
1967: Annual Meeting of American Society for Microbiology. Invited Lecture:
Antibiotic effect on intestinal flora and host immunologic defenses.
1968: Conferenceon Pathogenesis and Clinical Significance of Magnesium Deficiency at NY Acad Sciences. Chaired Session; Plenary lecture in session on Role of Chronic
Alcoholism in Magnesium Deficiency:
ECG patterns of magnesium depletion in alcoholic heart disease.
1970: Harvard School of Public Health, Invited Lecture:
Are opportunistic fungi solely a matter of deficient mechanisms in the host?
1970: Annual Meeting of American Society for Microbiology. Invited Lecture:
Antibiotic effect on intestinal flora and host immunologic defenses.
1970: Annual Meeting of International Study Group for Research in Cardiac Metabolism, Stowe, VT: Invited Lecture: Myocardial loss of functional magnesium.
1971: Chaired Plenary Session on Magnesium and the Cardiovascular System at First Int'l
Magnesium Sympos, Vittel, France; Plenary Lecture:Magnesium requirements.
1972: Symposium on Magnesium in Environment, Fort Valley State College, GA Invited Plenary Lecture: Contribution of magnesium deficit to human disease
(Lecture given by Co-Author, George E. Bunce-conflict with WHO meeting in Madrid.)
1972: WHO Workshop on Prevention of Ischemic Heart Disease, Madrid, Spain. Plenary Lecture, with Alexander Heggtveit: Magnesium interrelations in ischemic heart disease.
1972: Invited Lectures on Diagnosis of Candida Endocarditis
- City-wide closed circuit TV program on Infectious Disease
Conference of University of Cincinnati Medical School
- Medical Seminar at College of Physicians and Surgeons, Columbia Univ
- Grand Rounds at Commomnwealth of Virginia Medical College, Richmond
- City-wide Infectious Disease Conference, San Francisco
- Research Seminar: New Approaches - Diagnosis of Systemic Candidiasis, and Joint Infectious Disease/Cardiac Surgery Meeting, Stanford Univ Medical Center, Palo Alto
- Medical Grand Rounds, Downstate Medical Center, Brooklyn, NY.
1974: Emory University College of Medicine, Invited Lectures:
- Dept of Preventive Medicine:Magnesium requirements; role of magnesium deficit in disease.
- Department of Cardiology:Role of magnesium deficit in cardiology.
1974: Invited Lecture at Center for Disease Control, Atlanta: Candida serology; diagnosis & response to therapy of systemic candidiasis.
1974: Invited Lectures at Wisconsin University:
- Depts of Nutrition & Biochemistry:
Magnesium requirements and deficits in clinical disease.
- Dept of Biochemistry: Toxicities of Vitamin D and related sterols.
1976: 2nd Int'l Magnesium Symposium, Montreal, Canada; Plenary Session
Chairman on Magnesium & Cardiovascular System;gave 2 Plenary Session Lectures, with Francis J. Haddy (published, see 1980).
1976: Portland Med Ctr, Maine. Invited Lecture: Magnesium & heart disease.
1976: Grand Rounds, Mt Sinai Hospl, Elmhurst, NY: Magnesium in heart disease.
1977: 2nd Workshop on Vitamin D, California: Individual differences in susceptibility to
vitamin D- induced cardiovascular and renal damage; need to identify toxic metabolites.
1977: Roche Institute, Depts of Biochemical Nutrition, Cell Biology, & Immunology, Invited Lecture. Pharmacologic doses of anti-oxidant vitamins as possibly protective against D-
1977: New Jersey College of Medicine & Dentistry, Invited Lectures:
- Dept of Medicine, Martland Hospital. D-penicillamine and cirrhosis.
- Dept of Oral Biology. Candidiasis and the immune system.
1978: Uniformed Services Univ of Health Sciences, Dept of Physiology.
Bethesda Invited Lecture: Magnesium and cardiovascular disease.
1978: U.S. Dept of Agriculture Clinical Research Unit, Invited Lecture:
Magnesium deficiency and excesses of vitamin D and phosphate in development of
premature cardiovascular disease.
1979: Sympos on Inorganic & Nutritional Aspects of Cancer, Univ of San Diego, La Jolla, CA. Plenary Lecture: Magnesium and trace substances in the pathogenesis of cancer.
1979: U.S Dept of Agrice Res Unit, Grand Fork, ND. Invited Lecture: Pre- and perinatal Mg deficiency and other contributory nutritional factors in early onset cardiovascular disease.
1979: Minnesota Academy of Family Physicians Postgraduate Course, Invited Lecture: Magnesium in pregnancy and the newborn.
1979: Cardiology Grand Rounds, Mt. Sinai Medical Center, NY, NY. Invited Lecture: Magnesium's role in protecting the myocardium and against dysryhthmias in cardiac surgery and after acute myocardial infarction.
1979: Stress Symposium of the Selye Foundation, Monaco. Invited Lecture:
Magnesium and stress.
1980: Fox Chase Institute of Cancer Research, Philadelphia. InvitedLecture:Magnesium; trace substance deficiencies in pathogenesis of cancer.
1980: Minnesota Academy of Family Physicians Postgraduate Course, Invited Lecture:
Magnesium and the heart; treatment.
1980: Postgraduate Course at Northshore Univ Hospital. Invited Lectures:
-Prenatal and neonatal mineral deficiencies.
- Nutritional roots of combined system disorders.
1980: Int'l Sympos on Malnutrition in Pregnancy, Rome, Italy. Invited Lecture:
Magnesium deficiency in gestational and neonatal disorders.
1981: 5th Nat'l Sympos on Nutrition in Pregnancy, Univ of Louisville KY:
Magnesium deficiency in gestational and infantile disorders.
1981: 3rd Int'l Sympos on Magnesium, Baden, Baden Germany, Plenary Lecture:
Magnesium requirements in human nutrition.
1981: Seelig MS, Berger AR, Alba A, Sundar RP, Samaan NS, Becker MH: Magnesium treatment of myositis ossificans progressiva: Preliminary case report. 22nd Annual Meeting of Am College of Nutrition, Bethesda, MD, September 14-15.
1982: Boston Univ School of Medicine, Sympos on Intervention in the Aging Process. Invited Lecture: Possible roles of magnesium deficiency in aging.
1983: Swedish Cardiology Society Symposium. Invited Lecture: Possible contribution of magnesium deficiency to vulnerability of myocardium to ischemia.
1984: 1st European Congress on Magnesium, Lisbon, Portugal. Invited Lectures:
- Magnesium treatment of myositis ossificans progressiva.
- Magnesium deficiency and heart disease.
1984: British Cardiology Society, London, England. Invited Lecture: Possible contribution of intracellular shifts of myocardial magnesium to myocardial dysfunction of ischemia.
1984: Conference on Electrolytes and the Heart, Montveillon, France (unable to attend because of husband's illness; invited John Sheehan to co-author and attend Conference). Invited Lecture: Effect of magnesium treatment of arrhythmia associated with potassium loss.
1985: 4th Int'l Magnesium Symposium, Blacksburg, VA. Plenary Lectures:
- Effect of magnesium treatment in refractory arrhythmias (with J Sheehan)
- Rationale for treatment of calcinosis with magnesium.
1986: 2nd Europ Congr on Magnesium,Stockholm, Sweden.Plenary Lect.
1987: NY Medical College, Award Lecture:
Magnesium; trace minerals in cardiovascular disease.
1988: Workshop on Magnesium and Cardiovascular disease, NY, NY. Invited Lecture:
See Am J Cardiology, 1989, publications section for title.
1989: Univ of South Carolina Medical Center, Medical Dept. Invited Lecture:
Magnesium in epidemiology & treatment of cardiovascular disease.
1989: 2nd Meeting of Int'l Association for Vitamin and Nutritional Oncology.
Plenary Lecture: Magnesium/Nutrient Interactions in carcinogenesis.
1992: Seelig MS: Research into Magnesium and Diabetes Mellitus.
Consensus Panel, American Diabetes Association, New York City
1993: Seelig MS: Magnesium in immunologic abnormalities including asthma and other manifestations of allergy. Harman Award Lecture at Conference of American College for Advancement in Medicine, Minneapolis
1993: Seelig MS: Perinatal magnesium deficiency.Maimonides Med Ctr, NY
1995: Seelig MS: Use and misuse of pharmacologic doses of magnesium in eclampsia, myocardial infarction, asthma and as a cathartic or antacid.
Metropolitan Atlanta Nutrition Association.
1995: Seelig MS & Elin RJ: Plenary Lecture:Is there a place for Mg in Acute Myocardial
Infarction.At Vienna Conference at European Society of Magnesium
1996: Seelig MS: Mg in Acute Myocardial Infarction.at Cardiol Dept., NY Med Coll
A @ A @ A Duke Univ Med Ctr
A @ A @ A Salt Lake City Med Ctr
Mg deficiency in pathogenesis of cardiovascular diseasePhysiol & Cardiol Dept,
G Washington Univ, D.C.
Mg in the SAD (sudden arrhythmic death) Syndrome Salt Lake City Med Ctr
1996: Seelig MS: Is there a place for magnesium in the treatment of acute myocardial infarction?
5th European Magnesium Congress., Austria, June 16.
1996: Seelig MS: Might magnesium deficiency play a role in chronic fatigue syndrome?
Plenary Session paper at October 1996 Joint Meeting of the American College of Nutrition and the American Association for the Chronic Fatigue Syndrome
1997: Seelig MS, , Kenneth Weaver, Kay B. Franz, Burton M Altura:Suboptimal gestational magnesium: contributory to low birth weight and vascular infantile and adult disease.
Poster at Symposium on Advances in Clinical Nutrition, Am Coll Nutr, September
1997: Seelig MS: Magnesium inadequacy in conditions with the long QT, possibly including the SAD syndrome. Eighth International Symposium on Magnesium, Crete Greece
1997: Seelig MS: Grand Rounds: Mg in heart disease. St Vincent Hosp, Indianapolis
Mg in Acute Myocardial Infarction. Indiana Heart Institute
A @ A @ A Fuqua Heart Inst, Piedmont Hosp, Atlanta
A @ A @ A Univ Alabama, Mobile, Cardiol Dept
A @ A @ A Univ of Maryland Med Ctr, Cardiol Dept
A @ A @ A @of Illinois, Peoria
Similarities between latent tetany syndrome of Mg deficiency and the chronic fatigue syndrome and fibromyalgia Univ of Illinois, Peoria
1998: Seelig MS: Might patients with the chronic fatigue syndrome have latent tetany of magnesium deficiency? Plenary presentation, 6th Europ Mg Congress, Budapest 1998: Franz KV, Seelig MS: New dietary recommendations for magnesium,calcium,phosphorus, and vitamin D; some concerns. (presentation, 6th Europ Mg Congress, Budapest.)
1999: Seelig MS: Occult magnesium deficiency, insulin resistance and the cardiovascular metabolic disease syndrome. Gordon Research Conference on Mg
1999: Seelig MS:Stress Reactions in Magnesium Deficiency.presentation at International Congress for Assessment of Stress Intensity and Stress compatibility in Large Groups, Austria, Nov.
2000: Seelig MS: Plenary Session Talks: at International Association of International & American Nutrition, August 25-27, 2000. Las Vegas, Nevada
1. Who is deficient in Mg and how do we recognize the deficiency
2. Mg as nature=s Ca-blocker
2000: Seelig MS: Epidemiologic data on magnesium deficiency associated ardiovascular disease and osteoporosis: consideration of risks of current recommendations for high calcium intakes. At 9th International Magnesium Symposium, September 10-15, 2000. Vichy, France
2000: Seelig MS: Epidemiology of water magnesium: evidence of contributions to health. At 9th International Magnesium Symposium, September 10-15, 2000.. Vichy, France
2000: Origins & development of my interest in Mg. Mildred S Seelig Award Lecture, at Great Lakes Medical Association. September 17-18, 2000, Pittsburgh, PA
2000: Magnesium deficiency: dietary practices that intensify the problem. Annual Seelig Award Lecture, at Annual Meeting of the American College of Nutrition. October 12-15, 2000, Las Vegas, Nevada
2001: Likelihood that prenatal Mg deficiency is contributory to low birth weight and to early onset cardiovascular disease. Gordon Research Conf, CA
2003. Seelig MS, Burton BM, AlturaBT:Mental benefits of estrogen replacement therapy
(ERT) in postmenopausal women; risks of cognitive loss and dementia intensified by i ignoring importance of magnesium. At 10th International Magnesium Symposium, Cairns, Australia, September, 2003. (Publ, J Am Coll Nutr, 2004)
2003. Seelig MS, Burton BM, AlturaBT: Cardovascular and skeletal benefits of estrogen replacement therapy in healthy postmenopausal women; risks intensified by
ignoring importance of magnesium.At 10th International Magnesium Symposium, Cairns, Australia, September, 2003. (Publ, J Am Coll Nutr, 2004)
2003: Rosanoff A, Seelig MS: Comparison of mechanism and functional effects of magnesium
and statin pharmaceuticals. At 10th International Magnesium Symposium, Cairns,
Australia, September, 2003. (Publ: J Am Coll Nutr, 2004)
2004: Seelig MS: Value of raising the magnesium to calcium intake ratio for health.
(European Congress on Magnesium, Cluj, Romania, in Press)
Seelig MS: Caution: Increased Calcium to Prevent Osteoporosis Requires Increased Magnesium for Cardiovascular Health
(Third International Congress on Cardiology, Taipei, Taiwan, Nov. 2004)
Seelig MS: Caution: Increased Calcium to Prevent Osteoporosis Requires
Increased Magnesium for Health
( Zumkley Magnesium Award Lecture, 10th International Clinical Nutrition Symposium,
Phuket, Thailand, December, 2004)
PUBLISHED ARTICLES IN PEER REVIEWED JOURNALS;
1960: Cummings JR, Tabachnick E, Seelig MS: Chemistry and pharmacology of carbonic anhydrase inhibitors. In JH Moyer & M Fuchs (Eds) Edema Mechanisms and Management. A Hahnemann Symposium on Salt and Water Retention. Publ WB Saunders Co. Phila, PA, 1960, pp 252-258.
1964: Seelig MS: The requirement of magnesium by the normal adult. Am J Clin Nutr 14:342-390
1965: Seelig MS: The role of antibiotics in the pathogenesis of candida infections. Am J of Med
1966: Seelig MS: Mechanisms by which antibiotics increase the incidence and severity of candidiasis and alter the immunological defenses. Bacteriological Rev 30: 442-459.
1967: Seelig MS: Penicillamine and The nephrotic syndrome. (Letter) JAMA, 199:177.
1969: Seelig MS:Electrocardiographic patterns of magnesium depletion in alcoholic heart disease.Ann NY Acad Sci 162:906-917.
1969: Seelig MS: Vitamin D and cardiovascular, renal, and brain damage in infancy and childhood. Ann NY Acad Sci. 147:537-582.
1970: Seelig MS: Are American children still getting an excess of vitamin D?
Hyperreactive children at risk.Clin Pediatr 9:380-383.
1970: Seelig MS:Hyper - Reactivity to vitamin D*. Medical Counterpoint, July 1970.
1971: Seelig MS: Human requirements of magnesium; factors that increase needs.in Proc 1st Int'l Sympos on Magnesium Deficit, Ed J Durlach, Amiot Press, Vittel, May 9-15, 1971, pp 10-28.
1972: Seelig MS: Myocardial loss of functional magnesium. I. Effect on mitochondrial integrity and potassium retention. In "Recent Advances in Studies on Cardiac Structure and Metabolism" 1, Eds E Bajusz & G Rona, 1970/1972, 615-625.
1972: Seelig MS:Myocardial loss of functional magnesium. II. In cardiomyopathies of different etiology. Ibid, In "Recent Advances in Studies on Cardiac Structure and Metabolism" 1, Eds E Bajusz & G Rona, 1970/1972, 626_638.
1972: Seelig MS: Review: Relationships of copper and molybdenum to iron metabolism.
Am J Clin Nutr 25:1022-1037.
1972: Seelig MS.& George E. Bunce:Contribution of magnesium deficit to human disease. Magnesium in the environment. Soils, crops, animals & man. Chapter 3: 61-107. Div of Agric.
1973: Seelig MS: Proposed role of copper-molybdenum interaction in iron-deficiency and iron- storage disease. Am J Clin Nutr 26:657-672.
1973: Seelig MS, Lehr D: Effects of estrogen on tissue magnesium content; possible influence on cardiovascular and bone disease. in Proc First Intl Mg Sympos, Vittel, France, 1971, Ed J Durlach, Publ Amiot Press, 2:250-255.
1973: Seelig MS, Vitale JJ: Lipids and magnesium deficit. Ibid, 515-522.
1973: Seelig MS, CP Speth, PJ Kozinn, EF.Toni, Claire LTaschdjian:Candida endocarditis after cardiac surgery. J Thoracic and CV Surgery. Vol.65, 4: 583-601
1974: Seelig MS, Heggtveit HA: Magnesium interrelationships in ischemic heart disease: A review.Am J Clin Nutr 27:59_79.
1974: Seelig MS, CP Speth, PJ Kozinn, CL Taschdjian, EF. Toni, P Goldberg:Patterns of Candida endocarditis following cardiac surgery: Importance of early diagnosis and therapy. Progress in cardiovascular diseases. Vol.XVIII, 2: 125-160.
1975: Seelig MS, Adolph R. Berger & Neil Spielholz: Latent tetany and anxiety, marginal magnesium deficit, and normocalcemia. Reprinted from diseases of the nervous system.
36, 8:461- 465.
1976: Seelig MS (letter to Editor): Ischaemic heart disease, vitamins D and A, and
magnesium. British Med J. 3:647_648.
1976: Seelig MS & V Linden: Multiple factors in the hyperlipidaemia of hypervitaminosis D.
British Med J. 4: 166.
1977: Seelig MS. & Berger AR: Do Trace Elements, Magnesium and Anti-Oxidants Protect
Against D-Penicillamine Toxicity? Trace Substances in Environmental Health-XI. 1977. pp. 243 - 251.
1977: Seelig MS: Introductory Comments. Nutritional and metabolic factors in early and
later life contributing to acute and chronic disease.In Nutritional Imbalances in Infant
& Adult Disease, Ed MS Seelig, SP Books, NY. (Proc.16th Ann Meeting, Am Coll Nutr, ‘75.
1977: Seelig MS, Massry SG: Hypomagnesemia and hypermagnesemia.
Clinical Nephrology, 7: 147-153, 1977.
1977: Seelig MS, Mazlen RG: Individual differences in susceptibility to vitamin D-Induced cardiovascular and renal damage: Need to identify and characterize its toxic metabolites.
Vitamin D biochemical, chemical and clinical aspects related to calcium metabolism, Eds A.W. Norman, K. Schaefer, J.W. Coburn, H.F. De Luca, D. Fraser, H.G. Grigoleit, D.V. Herrath. Publ Walter de Gruyter- Berlin - New York 1977, pp. 607-610.
1978: Seelig MS: Magnesium deficieny with phosphate and vitamin D excesses; role in pediatric cardiovascular disease?Cardiovasc Med 3:637-650.
1978: Seelig MS, Augusta Alba, Adolph R. Berger, Ante Rudez & Milton Tarlau: Pilot study of
D , vitamins and minerals in multiple sclerosis. J Clin Psychiatry 39:170 - 174, 1978.
1979: Seelig MS: Editorial foreword to Part II of Nutrition and Cancer, Eds vanEys J, Seelig MS, Nichols BL. Publ SP Medical & Scientific Books: pp157-158.
1979: Seelig MS: Magnesium (and trace substance) deficiencies in the pathogenesis of
cancer. Biol Tr Element Res 1:273-297,1979.
1979: Seelig MS, Berger AR, Hazzi C & Milstoc M : Long-term pilot trial of D-penicillamine,
minerals and vitamins in patients with advanced Laennec=s cirrhosis. Trace Substances
in Environmental Health-XIII. 1979 pp 389-400.
1979: Seelig MS, Goldberg P, Kozinn PJ, Berger AR: Fungal endocarditis: Patients at risk and their treatment. Postgraduate Medical Journal, 55: 632-641.
1980: Seelig MS: Contribution of magnesium deficiency to gestational and infantile
disorders. In Malnutrition in Pregnancy Ed L Zichella, Proc Intl Sympos, Rome, Italy 1980: 1980: Seelig MS, Berger AR, Avioli LA: Speculations on renal, hormonal, and metabolic aberrations in a patient with marginal magnesium deficiency. In Magnesium in Health &
Disease, Eds M Cantin, MS Seelig, PublSpectrum Press, NY pp 459-468.
1980: Seelig MS, Haddy FJ:Magnesium and the Arteries: I. Effects of magnesium deficiency on arteries and on retention of sodium, potassium, and calcium .In Magnesium in Health & Disease, Eds M Cantin, MS Seelig, Publ Spectrum Press, NY pp 605_638.
1980: Haddy FJ, Seelig MS: Magnesium and the arteries: II. Physiologic effects of electrolyte abnormalities on arterial resistance. Ibid, pp 639_657.
1980: Kontopoulos V, Seelig MS, Dolan J, Berger AR, Ross RS: Influence of parenteral administration of magnesium sulfate to normal pregnant and to preeclamptic women.
Ibid, pp 839-848.
1980: Ross RS, Seelig MS, Berger AR:Isolation of leukocytes for magnesium determination.
Ibid, pp 7-15.
1981: Seelig MS: Amphotericin B binding of Magnesium: Contribution of its toxicity, and therapeutic implications. Mg-Bul 3:80-84.
1981: Seelig MS: Magnesium Requirements in Human Nutrition. Magnesium Bull 3(1a):26-47.
1981: Seelig MS:Magnesium Deficiency in gestational and Infantile Disorders.
Seminar designed for practicing nutritionists. Louisville, Kentucky -March 9 -11, 1981.
1982: Seelig MS: Early nutritional roots of cardiovascular disease. In Nutrition and Heart Disease Ed. HK Naito, Publ SP Med & Sci Books, New York, pp 31-59.
1982: Seelig MS:Nutritional roots of combined system disorders. In Clinical Disorders in Pediatric Nutrition. Ed F Lifshitz, Publ Marcel Dekker, NY, NY, pp 327-351.
1982: Seelig MS:Prenatal and neonatal mineral deficiencies: magnesium, zinc and chromium.
Nutrition. Ed F Lifshitz, Publ Marcel Dekker, NY, NY, pp 167-196.
1982: Seelig MS: Magnesium requirements in human nutrition.
Contemporary Nutrition. Vol. 7 , No. 1.
1982: Seelig MS:Auto - Immune Complications of D –penicillamine: A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr1:207-214.
1982: Seelig MS, Berger AR, Alba A, Sundar RP, Samaan NS, Becker MH: Magnesium treatment of myositis ossificans progressiva: Preliminary case report. J Am Coll Nutr: 112, 1982.
1983: Seelig MS:Possible role of magnesium in disorders of the aged.In AIntervention in
the Aging Process. A: Quantitation, Epidemiology, Clinical Research@. Eds W Regelson,
FM Sinex, Publ A Liss, NY, NY pp 279-305.
1983: Seelig MS:Vitamin D- risk vs. benefit. J Am Coll Nutr. 2: 109- 110.
1984: Sheehan JP, Seelig MS: Interactions of magnesium and potassium in the pathogenesis of cardiovascular disease. Magnesium 3: 301-314.
1985: Sheehan JP, Seelig MS:Magnesium, potassium and arrhythmias. J Am Coll Nutr 4:312- 313.
1986: Seelig MS: Nutritional status and requirements of magnesium, with consideration of individual differences and prevention of cardiovascular disease. Magnesium Bull 8:170- 185.
1988: Seelig MS: Overview: Recognizing the problem of magnesium deficiency.
In Trace Substances in Environmental Health - XXII, pp. 111-127.
1989: Seelig MS:Cardiovascular consequences of magnesium deficiency and loss; pathogenesis, prevalence and manifestations - magnesium and chloride loss in refractory potassium repletion.
Am J Cardiology 63:4G-21G
1990: Seelig MS: Increased magnesium need with use of combined estrogen and calcium for osteoporosis. Magnesium Res 3:197-215.
1991: Seelig MS (Editorial): Magnesium in acute myocardial infarction (International Study of Infarct Survival 4). Am J Cardiology 68:1221-1222.
1992: Seelig MS, Altura BT, Resnick LM, Handwerker SM, Altura BM: Low magnesium, a common denominator in pathologic processes in diabetes mellitus, cardiovascular disease, and eclampsia. J Am Coll Nutr 11:608
1992: Seelig MS: Adverse stress reactions in magnesium deficiency: Preventive and Therapeutic Implications. J Am Coll Nutr 11: 609, October 1992.
1993: Seelig MS: Interrelationship of magnesium and estrogen in cardiovascular and
bone disorders, eclampsia, migraine and premenstrual syndrome.
J Am Coll Nutr 12:442-458.
1994: Seelig MS(Editorial):Magnesium, antioxidants and myocardial infarction.
J Am Coll Nutr. 13:116-117, 1994.
1994: Seelig MS: Consequences of magnesium deficiency enhancement of stress
reactions; preventive and therapeutic implications.
J Am Coll Nutr 13:429-446. (Seelig Festschrift)
1994: Seelig MS. & Harry G. Preuss : Magnesium metabolism and perturbations in the elderly.
Kluwer Academic Publishers. Geriatric Nephrology and Urology. 4: 101 - 111.
1995: Seelig MS: Prenatal and genetic magnesium deficiency in cardiomyopathy;
possible vitamin and trace mineral interactions.In "Pediatric Nutrition XXI", Ed F
Lifshitz, CRC Press, Boca Raton, FL, pp 197-224.
1995: Seelig MS:Prenatal and neonatal mineral deficiencies: Magnesium, zinc, and chromium.
In AChildhood Nutrition A pp. 162-196.
1995: Seelig MS & Elin RJ (Editorial):Reexamination of magnesium infusions in
myocardial infarction.Am J Cardiol 76:172-173.
1995: Seelig MS: Interrelations between magnesium and calcium. in Ed G Berthon "Handbook on etal-Ligand Interactions in Biological Fluids" vol 1 (Part 2): Chapt 4, pp 273-286.
1995: Seelig MS: Calcium and magnesium deposits in disease, with emphasis on
arteriosclerosis. in Ed. G Berthon "Handbook on Metal-Ligand Interactions in
Biological Fluids" vol 2 (Part 4): Chapt 5, Dekker, N.Y., N.Y., pp 914-934.
1996: Seelig MS & Elin RJ: Is there a place for magnesium in the treatment of acute
myocardial infarction?.Am Heart J 132 (Part 2):471-477.
1996: Antman EM, Seelig MS, Fleischmann K, Lau J, Kuntz K, Berkey CS, McIntosh M:
Editorial. Magnesium in acute myocardial infarction: scientific, statistical, and
economic rationale for its use. Cardiovasc Drugs & Therapy 10:297-301.
1997: Seelig MS, Altura BM:Editorial. How best to determine magnesium requirement:
need to consider cardiotherapeutic drugs that affect its retention.
J Am Coll Nutr 16:4-6.
1997: Seelig MS, Altura BM: Editorial. How best to determine magnesium status; a new laboratory test worth trying. Nutrition: Intl J Appl & Basic Nutr Sci April (in press)
1998: Seelig MS, Elin RJ, Antman EM: Viewpoint: Magnesium in acute myocardial
infarction; still an open question.Canad J Cardiol 14:745-749.
1998: Seelig MS: Review and hypothesis: might patients with the chronic fatigue
syndrome have latent tetany of magnesium deficiency.
J Chron Fatigue Syndr 4:77-108.
1999: Rob PM, Dick K, Bley N, Seyfert T, Brinckmann CH, Hollriegel V, Friedrich HJ, Dibbelt L, Seelig MS: Can one really measure magnesium deficiency using the short-term magnesium loading test? J of Internal Medicine 246: 373-378.
2001: Seelig MS: Epidemiologic data on magnesium deficiency -associated
cardiovascular disease and osteoporosis ; consideration of risks of current
recommendations for high calcium Intake. In Advances in Magnesium research:
Nutrition and Health.@ Ed. Y Rayssiguier, Chapt 27, pp 177-190. Proc of 9th
International Symposium on Magnesium, Vichy, France.
2001: Seelig MS: Epidemiology of water magnesium; evidence of contributions to health. In AAdvances in Magnesium research: Nutrition and Health.@Ed. Y Rayssiguier, Chapt 32, pp 211-218. Proc of 9th International Symposium on Magnesium, Vichy, France.
2004: Seelig MS, Altura BM, Altura BT:Benefits and Risks of Sex Hormone Replacement in
Postmenopasal WomenPart 1: Cardiovascular and Skeletal Benefits of ERT;
Thrombophlebitic Compications Caused by Intensifying Pro-Coagulative Effect of Estrogen
by Low Magnesium/High Calcium Intakes; Part 2: Mental Benefits of Estrogen Replacement
with Magnesium Therapy after the Menopause; Cognitive Loss and Dementia Intensified
when Estrogen is Replaced without Magnesium Supplementation. J Am Coll Nutr23:4825-
4965. (Presentation at 10th International Magnesium Symposium, Australia; )
2004: Rosanoff A, Seelig MS:Comparison of mechanism and functional effects of magnesium
and statin pharmaceuticals. J Am Coll Nutr23:501S-505S. (Presentation at 10th
International Magnesium Symposium, Australia; )
2004: Seelig MS: Value of raising the magnesium to calcium intake ratio for health.
(European Congress on Magnesium, Cluj, Romania, in Press)